Cover Story: A conceptual model is presented on adaptive balance which defines the transition from fixed homeostasis to flexible homeodynamics, with a consequential progressive contraction of this adaptive capacity associated with the ageing phenotype. From metabolic flexibility to rigidity, this framework links mitochondrial dysfunction, impaired autophagy, NAD+ depletion, and oxidative stress to chronic disease. Ketosis, principally defined by the production of β-hydroxybut

Cover Story: The KetoSAge human trial examined ten lean, healthy, pre-menopausal women who were habitually in ketosis (~3.9 years). Participants suppressed ketosis-inducing hypoketonaemia for 21 days via a higher carbohydrate intake, aligned with standard healthy eating guidelines, before returning to euketonaemia. Hypoketonaemia resulted in significant increases in ALT (~1.9-fold), GGT (1.3-fold), ALT/AST (1.30-fold), GKI (22.23-fold), and HOMA-IR (2.13-fold). These metaboli

As a group of scientists, it became apparent that our research was unified by some common themes surrounding metabolic health, longevity, ageing, and age-related diseases. Given our range of scientific skills, experience, and technical expertise, we decided to work together to tackle some big questions surrounding diseases like diabetes, cancer, and liver disease. You can find out more about our individual research projects by checking out our About Us page. We are looking