Feature Paper: Restoring Homeodynamics: Autophagy, Ageing and the Metabolic Correction of Disease - Cover of the BIOCELL, Vol. 50, Issue 6 (June 2026)

Cover Story: A conceptual model is presented on adaptive balance which defines the transition from fixed homeostasis to flexible homeodynamics, with a consequential progressive contraction of this adaptive capacity associated with the ageing phenotype. From metabolic flexibility to rigidity, this framework links mitochondrial dysfunction, impaired autophagy, NAD+ depletion, and oxidative stress to chronic disease. Ketosis, principally defined by the production of β-hydroxybutyrate, represents a targeted strategy to restore homeodynamics and enhance physiological resilience. This cover image was created with AI-assisted digital illustration tools and refined by the authors. It contains no copyrighted elements or misleading scientific representations.